Cholesteryl Ester Transfer Protein Expressed in Lecithin Cholesterol Acyltransferase
نویسندگان
چکیده
Cheng-ai Wu, Maki Tsujita, Kuniko Okumura-Noji, Shinichi Usui, Hajime Kakuuchi, Mitsuyo Deficient Mice − Cholesteryl Ester Transfer Protein Expressed in Lecithin Cholesterol Acyltransferase Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2002 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000026297.50542.62 2002;22:1347-1353; originally published online June 13, 2002; Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/22/8/1347 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://atvb.ahajournals.org/content/suppl/2002/08/21/22.8.1347.DC1.html Data Supplement (unedited) at:
منابع مشابه
Cholesteryl ester transfer protein expressed in lecithin cholesterol acyltransferase-deficient mice.
OBJECTIVE Regulation of plasma cholesteryl ester transfer protein (CETP) concentration was studied in lecithin-cholesterol acyltransferase (LCAT)-knockout mice. METHODS AND RESULTS LCAT-knockout mice were cross-bred with CETP transgenic mice. The offspring (n=63) were classified for LCAT genotype and plasma CETP levels (no CETP, low CETP, and high CETP). High density lipoprotein (HDL) decreas...
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The mechanism responsible for the atherogenic lipoprotein changes associated with cigarette smoking are largely unknown. Lecithin: cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) are key factors in the esterification of plasma cholesterol and the transfer of cholesteryl ester from high-density lipoproteins (HDLs) toward very-low- and low-density lipoproteins (VL...
متن کاملPreferential enrichment of large-sized very low density lipoprotein populations with transferred cholesteryl esters.
The effect of lipid transfer proteins on the exchange and transfer of cholesteryl esters from rat plasma HDL2 to human very low (VLDL) and low density (LDL) lipoprotein populations was studied. The use of a combination of radiochemical and chemical methods allowed separate assessment of [3H]cholesteryl ester exchange and of cholesteryl ester transfer. VLDL-I was the preferred acceptor for trans...
متن کامل[Mechanisms of hypo and hyper alphalipoproteinemia in Chilean adults].
BACKGROUND High density lipoprotein (HDL) cholesterol is inversely associated to atherosclerotic cardiovascular risk. Disturbances in HDL cholesterol plasma levels are frequent in the Chilean population, however the pathophysiological mechanisms are unknown. AIM To evaluate the mechanisms involved in the hypo and hyper alfalipoproteinemias in Chilean subjects. MATERIALS AND METHODS Twenty t...
متن کاملLecithin:cholesterol acyltransferase and cholesteryl ester transfer activity from the isolated perfused rabbit liver.
Lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester (CE) transfer activity accumulate linearly in the recirculated medium of the isolated perfused rabbit liver. The appearance of both activities in the perfusate was blocked by the addition of 10 microM colchicine, indicating that these two proteins are synthesized and secreted by the liver. CE transfer activity catalyzed the net t...
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